An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared to 20% of men receiving placebo. A later analysis demonstrated that 36% of men using the alprostadil cream had a clinically relevant improvement in vaginal penetration ability and 31% clinically relevant improvement in ability to have successful intercourse to ejaculation.
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Not enough info for you? No problem. Nerd out on all the causes of erectile dysfunction with research from the most trusted sources on the interwebs. If you have any questions or you think we missed something important, leave a comment or book a consultation with one of these trained professionals and we’ll get you on the way to a healthier manhood.
…have traditionally been classified as impotence (inability of a man to achieve or maintain penile erection) and frigidity (inability of a woman to achieve arousal or orgasm during sexual intercourse). Because these terms—impotence and frigidity—have developed pejorative and misleading connotations, they are no longer used as scientific classifications, having been…
This choice allows them to escape side effects such as incontinence and impotence. Times, Sunday Times (2016)Our utter impotence when faced with people who seriously want us all dead. Times, Sunday Times (2015)Researchers say it has a much lower risk of incontinence and impotence than conventional surgery. Times, Sunday Times (2008)The downturn has not coincided with political impotence and despair. Times, Sunday Times (2009)The magic blue pill is used for problems other than impotence and heart conditions. The Sun (2009)Because they can't face their own impotence in the reaches of time. Times, Sunday Times (2015)Or the opposite, husbands who suffered from impotence and a lack of confidence in the bedroom. The Times Literary Supplement (2013)Whereas treatment can have side-effects including impotence and incontinence. The Sun (2009)But it can cause harm - including impotence and incontinence. The Sun (2008)Your husband should talk to his GP about the impotence problem. The Sun (2012)Results must be confirmed by biopsy, which can cause infection, impotence and incontinence. Times, Sunday Times (2008)And that treatment has side-effects, including possible impotence and incontinence. The Sun (2009)The 1979 general election cast the party into 18 years of political impotence. Times, Sunday Times (2009)Heavy use can lead to insomnia, high blood pressure, heart problems and impotence. The Sun (2009)Yet the Left's rise to cultural power was accompanied by its descent into economic and political impotence. The Times Literary Supplement (2012)MEN'S health columns have done a great job at bringing'embarrassing' problems such as impotence out of the closet. The Sun (2009)Half of hospitals do not offer vital support for those dealing with cancer, including side-effects such as incontinence and impotence. Times, Sunday Times (2014)
Venous leaks: In order to maintain an erection, blood has to be supplied to and remain in the penis. Some research suggests that men with high blood pressure may have trouble maintaining an erection because the increased pressure forces blood out of the erectile tissues of the penis and into the veins. In this theory, the “push” on the small closing valves of the veins is stronger than the veins’ ability to resist, meaning the veins can't “close” tightly enough to stop blood from passing out of the penis.
When looking at the potential causes of erectile dysfunction, it's important to understand that often more than one factor is involved or, as the American Urological Association puts it, "erectile function is the result of a complex interplay between vascular, neurologic, hormonal, and psychologic factors." Keep this in mind as you read through the wide-ranging list of causes and risk factors for ED, which includes medications, health conditions, injury, smoking, and more.
Examples of common neurologic conditions that can lead to ED include cerebral vascular accident, multiple sclerosis, Parkinson’s disease, and spinal cord injury. Microvascular disease associated with diabetes is thought to compound the endothelial and neural injuries associated with this disease. Pelvic surgery may disrupt both neural and vascular pathways, resulting in ED.
Before taking any medication for erectile dysfunction, including over-the-counter supplements and herbal remedies, get your doctor's OK. Medications for erectile dysfunction do not work in all men and might be less effective in certain conditions, such as after prostate surgery or if you have diabetes. Some medications might also be dangerous if you:
L-arginine, an amino acid that is naturally present in the body and helps make nitric oxide, supports a successful erection. Nitric oxide is responsible for making the blood vessels relax, which helps sustain an erection for men. A 1999 study, observed the effects of six weeks of high-dose (5 grams/day) orally administered nitric oxide (NO) donor L-arginine on men with organic ED. Thirty-one percent of those who took 5 grams/day of L-arginine experienced significant improvements in sexual function. Burns told Medical Daily, “l-arginine and deer antler velvet” have been the most popular go-to natural treatments for men.
Of the drugs used for depression, tricyclic antidepressants may be associated with erectile problems and other drugs may be substituted to prevent this complication. Currently available substitutes include bupropion, nefazodone, and trazodone. The selective serotonin reuptake inhibitors (eg, fluoxetine, sertraline, paroxetine, citalopram) can also cause difficulties with ED, but they might also have other significant sexual side effects, including decreased libido and anorgasmia.
Circulatory problems: An erection occurs when the penis fills with blood and a valve at the base of the penis traps it. Diabetes, high blood pressure, cholesterol, clots, and atherosclerosis (hardening of the arteries) can all interfere with this process. Such circulatory problems are the number one cause of erectile dysfunction. Frequently, erectile dysfunction is the first noticeable symptom of cardiovascular disease.
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